Advances in targeted alpha therapy for prostate cancer

Systemic Targeted Alpha Radiotherapy for Cancer

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

Microdosimetry for Targeted Alpha Therapy of Cancer

Targeted alpha therapy (TAT) has the advantage of delivering therapeutic doses to individual cancer cells while reducing the dose to normal tissues. TAT applications relate to hematologic malignancies and now extend to solid tumors. Results from several clinical trials have shown efficacy with limited toxicity. However, the dosimetry for the labeled alpha particle is challenging because of the ...

Osteoclast-targeted therapy for metastatic prostate cancer

10.2217/14750708.5.1.63 © 20 Bone metastases and skeletal complications are major causes of morbidity in men with prostate cancer. Despite the osteoblastic appearance of bone metastases on imaging studies, patients with bone metastases have elevated markers of bone resorption, indicative of high osteoclast activity. Indeed, increased osteoclast activity is independently associated with higher r...

systemic targeted alpha radiotherapy for cancer

background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...

Advances in Targeted Drug Delivery